Program Information
The Study of Correlation Between Radiation Pneumonitis and The Variation of CT-Based Radiomics Features
Y Lu1,2*, G Gong1 , D Li2 , Y Yin1,2 , (1) Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China, (2) Shandong Normal University, Jinan, Shandong Province, China
Presentations
WE-RAM1-GePD-IT-4 (Wednesday, August 2, 2017) 9:30 AM - 10:00 AM Room: Imaging ePoster Theater
Purpose: To assess the correlation of the change in CT image radiomics features with radiation pneumonitis.
Methods: 31 lung cancer patients who received radiation therapy were retrospectively research in this study, all patients have diagnosed with grade ≥ 2 radiation pneumonitis. For each patient, planning CT images and replanning CT images after 40Gy radiation therapy were obtained, ipsilateral and contralateral lung were considered as region of interest (ROI). The radiomics features were extracted from ROI use radiomics software, including first-order and second-order statistics information, and the quantification indices of radiomics features were compared between planning CT images and replanning CT images.
Results: (1) In present study, 96 radiomics features were extracted from each CT image; (2) 22 features changed significantly in planning CT images between ipsilateral and contralateral lung; (3) 12 features changed significantly in replanning CT images between ipsilateral and contralateral lung; (4) 28 features of ipsilateral lung changed significantly between planning and replanning CT; (5) 28 features of contralateral lung changed significantly between planning and replanning CT.
Conclusion: Some CT image radiomics features changed significantly for planning and replanning CT images after 40Gy for patients with grade ≥ 2 radiation pneumonitis, it held potential ability to predict radiation pneumonitis.
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