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Metabolic Heterogeneity Obtained From 18F-FDG PET / CT Images for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

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H Deng

H Deng1,2*, G Gong2 , Y Yin1,2, (1) School of Medicine and Life Sciences, University of Jinan-Shandong Academy, Jinan, Shandong Province, (2) Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province


TU-L-GePD-IT-4 (Tuesday, August 1, 2017) 1:15 PM - 1:45 PM Room: Imaging ePoster Theater

Purpose: To study the spatial distribution of metabolic heterogeneity for locally advanced NSCLC based on pro-treatment 18F-FDG PET / CT images.

Methods: The pre-treatment PET/CT images of 33 patients with locally advanced NSCLC were collected. GTV was delineated on the PET/CT fusion images. Tumor metabolic sub-regions was segmented with threshold of 25%, 50% and 75% of maximum standard uptake values (SUVmax). The absolute volume and the volume ratio of each sub-region to the total tumor volume were calculated.

Results: The mean volume of all patient target volumes was 87.9±34.2 cc(range from 35-213.9 cc).The mean volume of under 25%SUVmax was 21.9±21.0 cc and the ratio to GTV was 21.5%±11.3%. The mean volume of range from 25% to 50%SUVmax was 43.0±34.0 cc and the ratio was 45.5%±13.8%. The mean volume of range from 50% to 75% SUVmax was 24.7±24.4 cc and the ratio was 24.4%±9.2%. The mean volume of over 75% SUVmax was 6.6±6.0 cc and the ratio was 8.5%±6.9%. The difference in the volume of each sub-region was statistically significant(P<0.05).

Conclusion: The metabolic heterogeneity of local advanced NSCLC should not be ignored, so the standard radiation dose could not ensure the local control. The individual radiotherapy dose according to the internal tumor metabolic heterogeneity should be given different patients.

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