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The Feasibility Study of Multiple CTs Based Optimization in IMPT

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X Wang

X Wang1,2*, X Zhu2 , L Liao3 , H Li2 , B Jiang2,4 , X Zhang2 , (1) Sichuan Cancer Hospital, Chengdu, Sichuan, (2) UT MD Anderson Cancer Center, Houston, TX, (3) Global Oncology One inc., Houston, TX, (4) Tianjin Medical University Cancer Institute and Hospital, Tianjin, China


SU-I-GPD-T-101 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose: Intensity modulated proton therapy (IMPT) is sensitive to anatomy changes, and adaptive planning is need. The aim of this study was to evaluate the feasibility of combining patient’s multiple CTs to optimize an adaptive plan, in terms of reducing times of adaptive plan needed.

Methods: This was a retrospective study. Three patients with lung cancer who were treated with IMPT at our institution were selected in this study. Three CTs, named CT1, CT2 and CT3 according to the scanning date, were acquired for each patient. Multi-field optimization plans were developed on an in-house treatment planning system. For each patient, multiple CTs based optimization (M-CTO) and single CT based optimization (S-CTO) were used to develop original plans for CT3. M-CTO combined information of CT1 and CT2, and S-CTO used information of CT2 only. Dose volume histograms (DVHs) and isodose distribution were compared to evaluate differences between M-CTO plan and S-CTO plan on CT3.

Results: For M-CTO plan and S-CTO plan, DVHs and isodose distribution are identical on CT3. However, M-CTO plans are worse as compared with original plans on CT2.

Conclusion: Our preliminary results indicate that M-CTO cannot improve the quality of an adaptive plan as compared to S-CTO, and cannot reduce the adaptive plan required during treatment. Additional large numbers of patient are required to validate the feasibility of multiple CTs based optimization in IMPT.

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