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Effects of Therapeutic Radiation On Sperm in Prostate External Radiotherapy

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A Ataei

A Ataei*, T Leventouri , S Pella , Florida Atlantic University, 21st Center Oncology,Advanced Radiation Physic, Boca Raton, Florida


SU-I-GPD-J-92 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose: We evaluate the effects of radiation on the quality of the sperm during and after radiation treatment of prostate cancer. Our hypothesis is that not only the quantity of the sperm is changing but also its quality.

Methods: This is a statistical analysis based on biological effectiveness of the prescribed dose (BED), tumor control probability (TCP), and normal tumor complications probability (NTCP). Calculations on 30 patients’ data who had received an average of 79 Gy were performed. All patients had the seminal vesicles included at least in the first 45 Gy of treatment. The ratios α/β for the critical organs, the proliferation and doubling time were used in calculating the TCP and NTCP. The total follow-up time in this study will be 5 years.

Results: We have found some short term radiation effects, which tend to disappear over time. While no changes in sperm during the treatment were found, the later results show 1 – 3% decrease in sperm’s life span, and 2-3 % decrease in the sperm’s quality .

Conclusion: Based on this study, we expect no significant variations in sperm production and in its quality are expected 2-3 years after treatment. However, we suggest that the patient stores sperm before treatment to eliminate even a very small chance that radiotherapy could affect any children conceived during treatment.

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