| HyTEC 10 - Head and Neck Tumor Control Probability:
Radiation Dose - Volume Effects in Stereotactic
Body Radiation Therapy for Locally Recurrent
Previously-Irradiated Head and Neck Cancer:
Report of the AAPM Working Group (2018) Category: HyTEC In a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally recurrent previously irradiated head and neck cancer, data from more than 300 cases in 8 publications suggest that there is a doseeresponse relationship with superior local control and possibly improved overall survival, for doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. Stereotactic body radiation therapy doses equivalent to 5 fraction doses of 40 to 50 Gy are suggested for retreatment. International Journal of Radiation Oncology*Biology*Physics https://doi.org/10.1016/j.ijrobp.2018.01.044 John A. Vargo, MD, Vitali Moiseenko, PhD, Jimm Grimm, PhD, Jimmy Caudell, MD, David A. Clump, MD, PhD, Ellen Yorke, PhD, Jinyu Xue, PhD,# Yevgeniy Vinogradskiy, PhD, Eduardo G. Moros, PhD, Panayiotis Mavroidis, PhD, Sheena Jain, MD, Issam El Naqa, PhD, Lawrence B. Marks, MD, and Dwight E. Heron, MD, MBA, FACRO, FACR |
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