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Feasibility Study of Fe3O4/TaOx Nano Particles as a Radiosensitizer for Radiation Therapy

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S Ahn

S Ahn1*, N Lee2 , S Shin3 , C Choi3 , Y Han3 , H Park3 , D Choi3 , D Lim3 , (1) Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University ,(2) School of Advanced Materials Engineering College of Engineering, Kookmin Uiniversity,(3) Samsung Medical Center, Sungkyunkwan University School of Medicine radiation oncology


SU-F-T-662 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

To investigate the feasibility of using multifunctional Fe₃O₄/TaOx(core / shell) nano particles developed for CT and MRI contrast agent as dose enhancing radiosensitizers.

Firstly, to verify the imaging detectability of Fe₃O₄/TaOx nano particles, in-vivo tests were conducted. Approximately 600 mg/kg of 19 nm diameter Fe₃O₄/TaOx nano particles dispersed in phosphate buffered saline(PBS) were injected to ten nude Balb/c mice through the tail vein. Difference between pre- and post-injection images was analyzed by computing the pixel histogram and correlation coefficient factor using MATLAB in the user defined ROI.
Secondly, to quantify the potential therapeutic enhancement with nano materials, DER (Dose Enhancement Ratio) and number of SER (Secondary Electron Ratio) were computed using TOPAS(ver.2.0 P-03) MC simulation.

In CT, MRI imaging, the aorta, the blood vessel, and the liver were clearly visualized after intravenous injection of Fe₃O₄/TaOx nano particles. There was large different between pre and post-injection images of Histogram data and Coefficients of correlation factor in CT and MR are 0.006, 0.060, respectively. When 70 MeV protons were irradiated for a Gold, Tantalum, TaOx, Fe₃O₄/TaOx, Fe₃O₄ nano particle, DER was 2.59, 2.41, 1.68, 1.54 and 1.36 respectively. Similarly, SER increment was 2.31, 2.15, 1.56, 1.46, and 1.27 for Gold, Tantalum, TaOx, Fe₃O₄/TaOx, Fe₃O₄ nano particle, respectively.

Fe₃O₄/TaOx nano particles have potential as a multifunctional agent which enhances the accuracy in cancer detection through visualization of developed tumor lesion and increases the therapeutic effect in proton therapy. The dose enhancement with Fe₃O₄/TaOx was estimated as half of the Gold. However, tumor targeting such as combined with magnetic field may overcome the low DER.

Funding Support, Disclosures, and Conflict of Interest: This research was supported by the NRF funded by the Ministry of Science, ICT & Future Planning (2012M3A9B6055201 and 2012R1A1A2042414), Samsung Medical Center grant[GFO1130081]

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