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A Prototype System for Portal Imaging for Intensity Modulated Neutron Therapy

S St. James

S St. James1*, G Moffitt2 , D Argento1 , D DeWitt1 , R Miyaoka1 , R Stewart1 , (1) University of Washington, Seattle, WA, (2) University of Utah, Salt Lake City,, Utah,


SU-F-J-196 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose: Fast neutron therapy is offered at the University of Washington Medical Center for treatment of selected cancers. The hardware and control systems of the UW Clinical Neutron Therapy System are undergoing upgrades to enable delivery of IMNT. To clinically implement IMNT, dose verification tools need to be developed. We propose a portal imaging system that relies on the creation of positron emitting isotopes (¹¹C and ¹⁵O) through (n, 2n) reactions with a PMMA plate placed below the patient. After field delivery, the plate is retrieved from the vault and imaged using a reader that detects the annihilation photons. The pattern of activity produced in the plate provides information to reconstruct the neutron fluence map that can be compared to fluence maps from Monte Carlo (MCNP) simulations to verify treatment delivery. We have previously performed Monte Carlo simulations of the portal imaging system (GATE simulations) and the beam line (MCNP simulations). In this work, initial measurements using a prototype system are presented.

Methods: Custom electronics were developed for BGO detectors read out with photomultiplier tubes (previous generation PET detectors from a CTI ECAT 953 scanner). Two detectors were placed in coincidence, with a detector separation of 2 cm. Custom software was developed to create the crystal look up tables and perform a limited angle planar reconstruction with a stochastic normalization. To test the initial capabilities of the system, PMMA squares were irradiated with neutrons at a depth of 1.5 cm and read out using the prototype system. Doses ranging from 10-200 cGy were delivered.

Results: Using the prototype system, dose differences in the therapeutic range could be determined.

Conclusion: The prototype portal imaging system is capable of detecting neutron doses as low as 10-50 cGy and shows great promise as a patient QA tool for IMNT.

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