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The Joint ESTRO-AAPM Symposium: Imaging Markers for Assessment of Treatment Response

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G Meijer
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U van der Heide

S Bowen

G Meijer1*, U Van der Heide2*, S Bowen3*, (1) University Medical Center Utrecht, Utrecht, Netherlands, (2) The Netherlands Cancer Institute, Amerstdam, The Netherlands, (3) University of Washington, School of Medicine, Seattle, WA


MO-DE-303-0 (Monday, July 13, 2015) 1:45 PM - 3:45 PM Room: 303

This session will focus on quantitative imaging for assessment of tumor response to radiation therapy. This is a technically challenging method to translate to practice in radiation therapy. In the new era of precision medicine, however, delivering the right treatment, to the right patient, and at the right time, can positively impact treatment choices and patient outcomes. Quantitative imaging provides the spatial sensitivity required by radiation therapy for precision medicine that is not available by other means.

In this Joint ESTRO-AAPM Symposium, three leading-edge investigators will present specific motivations for quantitative imaging biomarkers in radiation therapy of esophageal, head and neck, locally advanced non-small cell lung cancer, and hepatocellular carcinoma. Experiences with the use of dynamic contrast enhanced (DCE) MRI, diffusion-weighted (DW) MRI, PET/CT, and SPECT/CT will be presented. Issues covered will include: response prediction, dose-painting, timing between therapy and imaging, within-therapy biomarkers, confounding effects, normal tissue sparing, dose-response modeling, and association with clinical biomarkers and outcomes. Current information will be presented from investigational studies and clinical practice.

Learning Objectives:
1. Learn motivations for the use of quantitative imaging biomarkers for assessment of response to radiation therapy
2. Review the potential areas of application in cancer therapy
3. Examine the challenges for translation, including imaging confounds and paucity of evidence to date
4. Compare exemplary examples of the current state of the art in DCE-MRI, DW-MRI, PET/CT and SPECT/CT imaging for assessment of response to radiation therapy

Funding Support, Disclosures, and Conflict of Interest: Van der Heide: Research grants from the Dutch Cancer Society and the European Union (FP7) Bowen: RSNA Scholar grant

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