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Automating Liver Segmentation Via Combined Global and Local Optimization

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D Li

Dengwang Li1*, Jie Wang2 , Daniel S. Kapp3 , Lei Xing4 , (1) College of Physics and Electronics, Shandong Normal University, Jinan, Shandong, (2) College of Physics and Electronics, Shandong Normal University, Jinan, Shandong, (3) Department of Radiation Oncology,Stanford University School of Medicine, Stanford, California, (4) Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California,


SU-E-J-130 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall

The aim of this work is to develop a robust algorithm for accurate segmentation of liver with special attention paid to the problems with fuzzy edges and tumor.
200 CT images were collected from radiotherapy treatment planning system. 150 datasets are selected as the panel data for shape dictionary and parameters estimation. The remaining 50 datasets were used as test images. In our study liver segmentation was formulated as optimization process of implicit function. The liver region was optimized via local and global optimization during iterations. Our method consists five steps: 1)The livers from the panel data were segmented manually by physicians, and then We estimated the parameters of GMM (Gaussian mixture model) and MRF (Markov random field). Shape dictionary was built by utilizing the 3D liver shapes. 2)The outlines of chest and abdomen were located according to rib structure in the input images, and the liver region was initialized based on GMM. 3)The liver shape for each 2D slice was adjusted using MRF within the neighborhood of liver edge for local optimization. 4)The 3D liver shape was corrected by employing SSR (sparse shape representation) based on liver shape dictionary for global optimization. Furthermore, H-PSO(Hybrid Particle Swarm Optimization) was employed to solve the SSR equation. 5)The corrected 3D liver was divided into 2D slices as input data of the third step. The iteration was repeated within the local optimization and global optimization until it satisfied the suspension conditions (maximum iterations and changing rate).
The experiments indicated that our method performed well even for the CT images with fuzzy edge and tumors. Comparing with physician delineated results, the segmentation accuracy with the 50 test datasets (VOE, volume overlap percentage) was on average 91%-95%.
The proposed automatic segmentation method provides a sensible technique for segmentation of CT images.

Funding Support, Disclosures, and Conflict of Interest: This work is supported by NIH/NIBIB (1R01-EB016777), National Natural Science Foundation of China (No.61471226 and No.61201441), Research funding from Shandong Province (No.BS2012DX038 and No.J12LN23), and Research funding from Jinan City (No.201401221 and No.20120109).

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