Program Information
Potential of Using Cerium Oxide Nanoparticles (CONP) for Protecting Healthy Tissue During Accelerated Partial Breast Irradiation (APBI)
m mainali1*, W Ngwa2 , G Cifter3 , J Celli4 , (1)University of Massachusetts Boston/Dana Farber cancer institute, Boston,MA,(2) Harvard Medical School, Boston, MA, (3) University of Massachusetts Lowell/ Dana Farber cancer institute, Boston, MA, (4) University of Massachusetts Boston, Boston, MA
Presentations
TU-G-CAMPUS-T-11 (Tuesday, July 14, 2015) 5:30 PM - 6:00 PM Room: Exhibit Hall
Purpose:
The purpose of this research is to investigate the feasibility of using targeted cerium oxide nanoparticles (CONP) during APBI to protect healthy cells.
Methods:
In one approach, CONP are assumed to be incorporated in a micrometer-thick polymer film on the surface of routinely used mammosite balloon applicators for sustained in-situ release of the CONP. In case two, CONPs are administered directly into the lumpectomy cavity. The concentration of H₂O₂ produced by ionizing radiation was estimated from previously published work using short range linear extrapolation. The assessment of CONPs concentration required to absorb corresponding H₂O₂ to protect healthy tissue was calculated. Fick’s Second law of diffusion was employed to determine the initial concentration of CONP needed to achieve the minimum concentration for radioprotection at distance 1 cm and 2 cm from the lumpectomy cavity during APBI. The study was carried out for different nanoparticle sizes.
Results:
The initial concentration of CONPs required to get desired radioprotection concentration at 1 cm and 2 cm after 7 days was found to be 0.4089 mg per Kg and 59.7605 g per Kg respectively for 2 nm size nanoparticles. Using concentrations of 5 mg per kg of CONP that have been shown to be used to confer radioprotection (for about 7.97 Gy) in experiments it was observed that 4.5631, 8.5286, 10.9247, 22.0408, 43.6796 and 65.5618 number of days are required to achieve radioprotection at 1 cm for CONP of sizes 2 nm, 3.8 nm, 5 nm, 10 nm, 20 nm, 30 nm, respectively.
Conclusion:
Our preliminary results show that smaller size (2 nm and 3.8 nm) CONP would be suitable as radio protectant during APBI because they took a reasonable number of days, i.e. less than 10 days to reach tissues of 1 cm or 2 cm thickness.
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