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Dosimetric Accuracy of Multitarget Single Isocenter Radiosurgery

F Tannazi

F Tannazi*, M Huang , E Thomas , J Duan , X Wu , S Shen , R Cardan , J Fiveash , I Brezovich , R Popple , University of Alabama at Birmingham, Birmingham, AL.


SU-E-T-291 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose:To evaluate the accuracy of single-isocenter multiple-target VMAT radiosurgery (SIMT-VMAT-SRS) by analysis of pre-treatment verification measurements.

Methods:Our QA procedure used a phantom having a coronal plane for EDR2 film and a 0.125 cm3 ionization chamber. Film measurements were obtained for the largest and smallest targets for each plan. An ionization chamber measurement (ICM) was obtained for sufficiently large targets. Films were converted to dose using a patient-specific calibration curve and compared to treatment planning system calculations. Alignment error was estimated using image registration. The gamma index was calculated for 3%/3 and 3%/1 mm criteria. The median dose in the target region and, for plans having an ICM, the average dose in the central 5 mm was calculated.

Results:The average equivalent target diameter of the 48 targets was 15 mm (3-43 mm). Twenty of the 24 plans had an ICM for the plan corresponding to the largest target (diameter 11-43 mm) with a mean ratio of chamber reading to expected dose (ED) and the mean ratio of film to ED (averaged over the central 5 mm) was 1.001 (0.025 SD) and 1.000 (0.029 SD), respectively. For all plans, the mean film to ED (from the median dose in the target region) was 0.997 (0.027 SD). The mean registration vector was (0.15,0.29) mm, with an average magnitude of 0.96 mm. Before (after) registration, the average fraction of pixels having gamma < 1 was 99.3% (99.6%) and 89.1% (97.6%) for 3%/3mm and 3%/1mm, respectively.

Conclusion:Our results demonstrate dosimetric accuracy of SIMT-VMAT-SRS for targets as small as 3 mm. Film dosimetry provides accurate assessment of the absolute dose delivered to targets too small for an ionization chamber measurement; however, the relatively large registration vector indicates that image-guidance should replace laser-based setup for patient-specific evaluation of geometric accuracy.

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