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Task Group No. 256 Proton Relative Biological Effectiveness (RBE)
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1. Assess whether the current practice of a constant clinical RBE should be revised or maintained. 2. Assess the potential and clinical consequences of delivering RBE weighted doses based on variable LET distributions and as a function of dose and biological endpoints and assess the potential for harm and benefits associated with the clinical implementation of alternate (non-constant) RBE and dose-weighted LET models into treatment planning systems in terms of treatment margins and other metrics. 3. Recommend experiments needed to improve our current understanding of the relationships among in vitro, in vivo and clinical RBE and develop recommendations to minimize the effects of uncertainties associated with proton RBE for well defined tumor types and critical structures. 4. Review biophysical models to potentially predict RBE in a treatment planning environment and provide LET and RBE relationships from such models.

Bylaws:Not Referenced.Rules: Not Referenced.
Approved Date(s)Start: 12/1/2013
End: 12/31/2015
Committee Keywords: TG256
Board of Directors  [Status]
Science Council  [Status]
Therapy Physics  [Status]
Treatment Delivery SC  [Status]
Work Group on Particle Beams  [Status]
TG256 Proton Relative Biological Effectiveness (RBE) Proton Relative Biological Effectiveness (RBE) [Status]
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Chair

Harald Paganetti
Task Group Chair


Members - 2014 Roster

(dates shown below are beginning date of position) View 2015 Roster

There are 14 members and guests.
=complete and up-to-date, =complete, out-of-date, =incomplete conflict of interest statement.
Eleanor Blakely

up-to-date
12/10/2013  Consultant - (nonvoting)
Alejandro Carabe-Fernandez, PhD

out-of-date
12/1/2013  Member -
David J. Carlson, PhD

up-to-date
12/1/2013  Member -
Indra J. Das, PhD

up-to-date
12/1/2013  Member -
Lei . Dong, PhD

up-to-date
12/1/2013  Member -
David Grosshans

out-of-date
12/10/2013  Consultant - (nonvoting)
Kathy Held

out-of-date
12/10/2013  Consultant - (nonvoting)
Michael C. Joiner, PhD

up-to-date
10/3/2014  Member - (nonvoting)
Radhe Mohan, PhD

out-of-date
12/1/2013  Member -
Vitali Moiseenko, PhD

up-to-date
12/1/2013  Member -
Andrzej Niemierko, PhD

out-of-date
12/10/2013  Member -
Harald Paganetti, PhD

up-to-date
12/1/2013  Task Group Chair -
Robert D. Stewart, PhD

up-to-date
12/1/2013  Member -
Henning Willers, M.D.

up-to-date
12/10/2013  Consultant - (nonvoting)

Staff Assigned to Committee - 2014 Roster

(dates shown below are beginning date of position)
No Current Members