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Non-Coplanar Cone Beam CT Reconstruction with Limited Angle of Projections Using Rigid Image Registration Facilitated Prior Image Constrained Compressed Sensing

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B Meng

B Meng*, R Li, B Han, J Cheng, L Xing, Stanford Univ School of Medicine, Stanford, CA

TH-C-103-6 Thursday 10:30AM - 12:30PM Room: 103

Purpose: The purpose of this work is to develop a non-coplanar cone beam CT (CBCT) image reconstruction method from limited angle of projections.

Methods: Planning CT or CBCT acquired at neutral position (without couch rotation/translation) serves as the prior images for successive reconstruction. During the course of radiation therapy, subsequent CBCT scans are acquired from limited angle of projections. An iterative reconstruction algorithm, using prior image constrained compressed sensing (PICCS) framework and rigid image registration, is incorporated to reconstruct the patient image under non-coplanar geometry. The prior reconstructed image is rotated/translated according to the nominal couch rotation/translation to serve as the prior input of the compressed sensing based iterative optimization. First, The PICCS framework can be solved iteratively using the total variation minimization step and the iterative image reconstruction step with simultaneous algebraic reconstruction technique (SART). Then, rigid image registration between the reconstructed image and the rotated/translated prior image is applied to further calibrate the rotation/translation of the prior image. The iterations of PICCS algorithm and rigid image registration continue until the registration results are below the predetermined threshold. The proposed reconstruction algorithm is evaluated with both digital phantom simulations and experimental data.

Results: The proposed CBCT reconstruction algorithm significantly improved the image quality from projections with angular range as small as 72 degrees. It can reduce the rigid translational setup errors under from 8 mms to below 1 mm and the rigid rotational setup error from 5 degrees to below 1 degree. Compared with the original PICCS algorithm alone, the rigid registration step helps to improve the convergence of algorithm significantly.

Conclusions: The proposed algorithm provides an accurate remedy for solving the problem of non-coplanar CBCT reconstruction from limited angle of projections by taking advantage of the combination of PICCS framework and rigid image registration.

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