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The Role of Conventional MR Physics, Resting State Functional MR Physics and MR Spectroscopy for the In-Situ Monitoring of Infarct and Peri-Infarct Tissue and for the Precise Diagnosis of Acute Ischemic Stroke

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M Kasam

M Kasam1*, (1) Mayo Clinic, Rochester, MN

SU-E-E-5 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose:
There has been great interest to understand the detection mechanism of the growth of infarct region to periinfarct region (Perfusion Weighted Imaging, PWI and Diffusion weighted Imaging, DWI) in the brain of acute ischemic stroke patients using the principles of MR Physics as it would significantly affects the clinical diagnosis.
Similarly, aiding resting state functional Magnetic resonance (fMRI) physics and MR spectroscopic (MRS) principles to the above to the diagnostic clinician will help as these mechanisms are more sensitive to the above changes due to the similar metabolic activity of the tissue under risk (periinfarct) and the dead tissue (infarct). This presentation aims to provide an overview of conventional principles (DWI and PWI) and emphasis the importance of resting state fMRI and MRS physics techniques for monitoring of infarct and peri-infarct tissue along with the growth of infarct region.

Methods and Results:
Organization of Methods and Results:
1: Introduction
Infarct and peri-infarct region activity after the acute stroke.
2: Review of the MR physics role of DWI, PWI, resting state fMRI, MRS and their descriptions with specific examples.
3: Detailed discussions on advantages and limitations of both conventional MR (DWI& PWI) and resting state fMRI and MRS physics techniques.

Conclusion:
The physics principles of monitoring resting state fMRI and MRS of the acute stroke patient along with the conventional MRI (PWI and DWI) can potentially help the clinical community in making precise diagnosis for the acute stroke patient.

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