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Real-Time Guidance and Planning in Breast High Dose Rate Brachytherapy Using 3D Ultrasound

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E Poulin

E Poulin1-4*, L Gardi2, A Fenster2, J Pouliot3, L Beaulieu1-4, (1) Universite Laval, Quebec, Qc, (2) Robarts Research Institute, London, ON, (3) UC San Francisco, San Francisco, CA, (4) Centre Hospitalier Univ de Quebec, Quebec, QC

MO-F-144-3 Monday 4:30PM - 6:00PM Room: 144

Purpose: In breast interstitial high dose rate (HDR) brachytherapy, the number and positions of the catheters are usually chosen manually using a preimplant CT scan. In this work, we present an innovative approach for real-time 3D ultrasound (3DUS) planning in breast HDR brachytherapy.

Methods: The end-to-end procedure was realized with a computer controlled robotic 3DUS system for breast brachytherapy so that both planning and guidance are possible. The scanner is mounted on the Kuske template (Nucletron, Veneendal, The Netherlands) so that the scan direction is longitudinal to the catheter axis. Software modules were developed for the acquisition and reconstruction of ultrasound images. A semi-automatic segmentation algorithm and a needle reconstruction algorithm were integrated into the software to segment the planning target volume and reconstruct the catheter. A Centroidal Voronoi Tessellations (CVT) algorithm, in conjunction with IPSA, was used for catheter number and position optimization. The procedure was tested with 9 catheters in an agarose-based phantom with a hypo-echoic mass.

Results: The 3DUS acquisition time is less than 7s and the catheter optimization algorithm can obtain 10 complete treatments plans, with the corresponding dosimetric indices, in 90s. The catheter optimization algorithm was shown to reduce the number of catheters to 12 without reducing the quality of the treatment. Breast PTV V100 and dose homogeneity index (DHI) calculated after the procedure were compared to the value obtained from the optimal plan calculated with the CVT algorithm. Both dosimetric indexes were still within RTOG guidelines after the procedure. However, the PTV V100 is smaller after the procedure due to the template-based implantation. Isodoses are comparable.

Conclusion: We have devised a simple, fast and efficient method for real-time 3DUS guidance of breast HDR brachytherapy. This approach could be coupled with personalized 3D-printed or robotic template to further optimize this brachytherapy procedure.


Funding Support, Disclosures, and Conflict of Interest: Funding support: CIHR and NSERC

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