Intensity Modulated Proton Therapy Plans with Multiple Fields for Prostate Cancer
S Dhanesar*, N Sahoo, M Kerr, M Taylor, P Summers, P Alvarez, R Wu, F Poenisch, X Zhu, M Gillin, The University of Texas M. D. Anderson Cancer Center, Houston, TexasSU-E-T-403 Sunday 3:00PM - 6:00PM Room: Exhibit Hall
Purpose: To investigate the possible improvements in the dose conformity in intensity modulated proton therapy (IMPT) plans with multiple fields as compared to widely used single field optimized (SFO) plans with two lateral fields for spot scanned proton therapy (SSPT) and to verify the accuracy of the delivered dose using the Radiological Physics Center Proton Prostate Phantom (RPCPPP).
Methods: The CT images of RPCPPP were used to design multiple IMPT plans using both SFO and multi field optimization (MFO) methods in the Varian Eclipse treatment planning system (TPS). The standard SFO clinical plan used two lateral fields going through the femoral heads. Non-standard plans were generated using three or more oblique fields based on the SFO and MFO options of the TPS. The angles were carefully chosen to avoid bladder and rectum as much as possible. The RPC phantom containing films and TLDs was irradiated using the standard clinical SFO plan and the four field MFO plan to compare the planned and delivered dose.
Results: Based on the DVHs, MFO plan with multiple oblique fields is found to have superior target conformity with reduced dose to organs at risk (OAR) and normal tissue, especially in the high dose regions, as compared to SFO plans. The point doses measured by TLDs and 2-D dose distribution measured by GafChromic films in the RPCPPP irradiation passed the commonly used RPC acceptance criteria, namely +/-7% agreement in point does and more than 85% of the voxels meeting the gamma index criteria of 7% dose or 4 mm distance agreement.
Conclusion: The MFO SSPT plans for prostatic targets with multiple fields lead to better target conformity with lower doses to OARs as compared to SFO plans. The results of irradiations of the RPCPPP show that these plans can be delivered with acceptable accuracy