| Question 1: In the final task of the Dosimetry Challenge participants were provided with the SPECT-based time-integrated activity map and co-registered organ/lesion contours for each patient. The task was to estimate the absorbed dose to lesions and organs. Not all participants obtained the same answers because |
| Reference: | Carlos Uribe, Avery Peterson, Benjamin Van, Roberto Fedrigo, Jake Carlson, John Sunderland, Eric Frey, Yuni K Dewaraja. An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 1: Design and Early Results of the SNMMI Dosimetry Challenge
Journal of Nuclear Medicine Dec 2021, 62 (Supplement 3) 36S-47S; DOI: 10.2967/jnumed.121.262748 |
| Choice A: | of variability in the contours |
| Choice B: | of variability in time-activity fitting |
| Choice C: | of variability in the SPECT/CT images |
| Choice D: | of variability in the method/software they used to estimate the absorbed dose |
| Question 2: Assuming perfect spatial resolution, the Local Energy Deposition (LED) approach is valid when |
| Reference: | Reference: Ljungberg M, Sjögreen Gleisner K. Personalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools. Biomedicines. 2016; 4(4):25. https://doi.org/10.3390/biomedicines4040025 |
| Choice A: | the range of radiation particles is greater than the voxel size |
| Choice B: | the radionuclide is an alpha or beta emitter |
| Choice C: | the range of radiation particles is less than the voxel size |
| Choice D: | the radionuclide is a gamma emitter |
| Question 3: A first-order, patient-specific organ mass correction of the beta component of MIRD anthropomorphic (e.g., adult female) reference phantom absorbed dose is |
| Reference: | Reference: Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med 2005; 46:1023-1027 |
| Choice A: | Reference phantom organ mass / patient organ mass raised to the 1/3 power |
| Choice B: | Reference phantom organ mass / patient organ mass |
| Choice C: | The square root of reference phantom organ mass / patient organ mass |
| Choice D: | Reference phantom organ mass / patient organ mass raised to the 2/3 power |
| Question 4: Which of the following imaging modalities DOES NOT provide information about the activity uptake in an organ or lesion? |
| Reference: | Reference: Bushberg JT, Seibert JA, Leidholdt EM, Boone JM, Goldschmidt EJ. The Essential Physics of Medical Imaging [Internet]. Vol. 30, Medical Physics. 2003. Available at: http://doi.wiley.com/10.1118/1.1585033 |
| Choice A: | Planar imaging |
| Choice B: | SPECT |
| Choice C: | PET |
| Choice D: | CT |
| Question 5: What source of variability is the dosimetry challenge not considering? |
| Reference: | Carlos Uribe, Avery Peterson, Benjamin Van, Roberto Fedrigo, Jake Carlson, John Sunderland, Eric Frey, Yuni K Dewaraja. An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 1: Design and Early Results of the SNMMI Dosimetry Challenge
Journal of Nuclear Medicine Dec 2021, 62 (Supplement 3) 36S-47S; DOI: 10.2967/jnumed.121.262748 |
| Choice A: | Segmentation |
| Choice B: | Camera calibration and image reconstruction |
| Choice C: | Curve fitting and time-integrated activity |
| Choice D: | S-value sources |
| Question 6: What imaging protocol is recommended to obtain the highest image quantification accuracy for dosimetry purposes for most therapy radionuclides? |
| Reference: | Reference: Siegel JA, Thomas SR, Stubbs JB, Stabin MG, Hays MT, Koral KF, Robertson JS, Howell RW, Wessels BW, Fisher DR, Weber DA, Brill AB. MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med. 1999 Feb;40(2):37S-61S
Dewaraja, Yuni K., Eric C. Frey, George Sgouros, A. Bertrand Brill, Peter Roberson, Pat B. Zanzonico, and Michael Ljungberg. 2012. “MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy.” Journal of Nuclear Medicine 53 (8): 1310–25. |
| Choice A: | Multiple SPECT/CT scans |
| Choice B: | A hybrid approach with one SPECT and multiple planar images |
| Choice C: | Multiple planar images |
| Choice D: | A PET image |
