2022 AAPM 64th Annual Meeting
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Session Title: From Pre-Clinical To Vet-Clinical Imaging and Therapy: Pathways to Clinical Translation
Question 1: National cancer institute (NCI) radiation research program workshop examined 6 randomized clinical trials from the Radiation Oncology Group that resulted in full outcomes. This result may be due, in part,
Reference:Coleman, C.N., et al. Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials. Clin Cancer Res 22, 3138-3147 (2016).
Choice A:Lack of sufficient patient outcome data.
Choice B:Not well-designed clinical trials.
Choice C:The quality and validity of the preclinical data.
Choice D:Lack of funding support for the trials.
Question 2: Optical tomography can be potentially used for radiation guidance in pre-clinical research because of its
Reference:Xu, X., et al. Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research. Int J Radiat Oncol Biol Phys 111, 1310-1321 (2021).
Choice A:Greater image resolution compared to CT.
Choice B:Strong soft tissue contrast.
Choice C:Time of fly information for fluorescence lifetime measurement
Choice D:Organ motion track capability.
Question 3: From all the FLASH irradiation studies, FLASH effects have been observed using:
Reference:Lin, B., Gao, F., Yang, Y., Wu, D., Zhang, Y., Feng, G., Dai, T. and Du, X. (2021) FLASH Radiotherapy: History and Future. Front Oncol 11, 644400.
Choice A:Protons only
Choice B:Electros only
Choice C:X-rays only
Choice D:Proton and electrons only
Choice E:Proton, electrons and x-rays
Question 4: Objectives of the VRTOG are all except for:
Choice A:Identify a group of clinical radiation oncology investigative centers dedicated to the principle of cooperative clinical trials and other research to improve the survival of animals with cancer
Choice B:Establish standardized treatment, reporting and quality assurance parameters so that uniformity exists in treatment plans, dosimetry and reproducibility of outcome in participating centers
Choice C:Define the minimum standards of radiation and ancillary equipment needed for participation in VRTOG clinical trials.
Choice D:To critically evaluate new methods of cancer treatment to improve local-regional control and survival.
Choice E:Fund basic education in veterinary radiation oncology.
Question 5: The physical interaction that is increases dose within material by a cubic factor with increase in atomic number ( ) is:
Reference:Khan’s The Physics of Radiation Therapy, Fiaz M. Khan John P Gibbons 5th ed. Page 64
Choice A:Compton scattering
Choice B:Photoelectric effect
Choice C:Positron annihilation
Choice D:Photodisintegration
Question 6: When considering the use of companion animals (pet dogs and cats) in translational oncology research including radiation studies, which of the following is TRUE?
Reference:Boss MK. Canine comparative oncology for translational radiation research. Int J Radiat Biol. 2022;98(3):496-505. doi: 10.1080/09553002.2021.1987572. Epub 2021 Oct 11. PMID: 34586958.
Choice A:Given their small size, dogs and cats are of limited use as models of human cancer.
Choice B:Most dogs and cats eat the same foods as people, so studies of nutritional impact on carcinogenesis are common.
Choice C:Pet dogs and cats share our environment and have intact, experienced immune systems.
Choice D:The use of pet dogs and cats in radiation research is unethical given the lack of translation to people.
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