2022 AAPM 64th Annual Meeting
Back to session list

Session Title: Advances in Image-Guided RT: Towards Real-Time and Biological Adaptation
Question 1: Lymphocyte counts measured in the blood during/after RT can give:
Reference:Grassberger, C., Ellsworth, S. G., Wilks, M. Q., Keane, F. K. & Loeffler, J. S. Assessing the interactions between radiotherapy and anti-tumour immunity. Nature reviews. Clinical oncology 16, 729–745 (2019).
Choice A:information about the patient-specific immune infiltration within the tumor
Choice B:a measure of global immune response in the patient, and correlate with overall survival in a range of indications
Choice C:are routinely used as input for predictive models
Choice D:none of the above
Choice E:all of the above
Question 2: Which factors can affect the patient-specific lymphocyte loss during radiotherapy?
Reference:Damen, P. J. J. et al. The influence of severe radiation-induced lymphopenia on overall survival in solid tumors: a systematic review and meta-analysis. Int J Radiat Oncol Biology Phys (2021) doi:10.1016/j.ijrobp.2021.07.1695.
Choice A:Fractionation regimen
Choice B:Integral dose delivered
Choice C:Irradiation of specific structures (spleen, bone marrow)
Choice D:none of the above
Choice E:all of the above
Question 3: Biophysical metrics of tracer transport following flow-based imaging can:
Reference:Sinno N, Taylor E, Milosevic M, Jaffray DA, Coolens C. Incorporating cross-voxel exchange into the analysis of dynamic contrast-enhanced imaging data: theory, simulations and experimental results. Phys Med Biol. 2021 Oct 14;66(20). doi: 10.1088/1361-6560/ac2205. PMID: 34650009.
Choice A:inform on the patient-specific microvasculature within the tumor
Choice B:be a measure diffusion of contrast agent in the intracellular intravascular space, and correlate with interstitial tumour pressure
Choice C:Be a measure of drug uptake in the tumour
Choice D:none of the above
Choice E:all of the above
Choice F:all of the above provided the fundamental cross-voxel transport is considered
Question 4: Regarding BgRT delivery, which one of the following is true?
Reference:Shirvani et al. Br. J. Radiol;93:20200873.
Choice A:PET signal was not required for BgRT delivery
Choice B:Limited-time-sampled (LTS) PET images were obtained to guide the RT delivery
Choice C:Due to limited PET detector array used, it takes several minutes to generate the limited-time-sampled (LTS) PET images
Choice D:The limited-time-sampled (LTS) PET images usually have much better image quality compared to the full PET volume scan
Question 5: What is a Biological Target Zone (BTZ)?
Reference:Shirvani et al. Br. J. Radiol;93:20200873.
Choice A:A novel detector that was utilized on PET Arc to improve the detector efficiency
Choice B:A target structure defined in BgRT planning which physician prescribed to.
Choice C:A novel tracer used in BgRT delivery.
Choice D:A bounding volume that eliminates interference from PET signals originating from structures other than tumor
Question 6: Which factors are not critical for current online adaptive MRI-guided radiotherapy procedures?
Reference:T. Stanescu, A. Shessel, C. Carpino-Rocca, E. Taylor, O. Semeniuk, W. Li, A. Barry, J. Lukovic, L. Dawson, A. Hosni. MRI-guided online adaptive stereotactic body radiation therapy of liver and pancreas tumors on an MR-Linac system. Cancers 14, 716, 2022. https://doi.org/10.3390/cancers14030716
Choice A:Strong imaging gradients
Choice B:Detailed electron density information assigned to organ tissues
Choice C:High quality functional imaging
Choice D:All of the above
Choice E:None of the above
Back to session list