Program Information
Photoacoustic Imaging for Prostate Cancer
S Tang1 , K Stratton2 , L Xiang1*, (1) School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK,(2) Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Ok
Presentations
WE-F-708-6 (Wednesday, August 2, 2017) 1:45 PM - 3:45 PM Room: 708
Purpose: Image-guided drug delivery is a novel strategy that combines the effect of therapy and visibility into one system. The purpose of this study was to optimize the configuration of a photoacoustic endoscope (PAE) for prostate cancer detection and drug delivery monitoring in prostate laser-based therapy.
Methods: We performed both theoretical calculations and simulations of this optimized PAE configuration on a three-dimensional (3D) prostate phantom with various tumor positions and therapeutic drug concentrations. The optical energy deposition was simulated by Monte Carlo methods with PAE placed in urethra and rectum, respectively. The initial pressure rises caused by optical energy deposition were calculated based on the thermoacoustic properties of different tissue types. PA wave propagation and detection were then simulated by Matlab K-Wave toolbox. The PA images of the prostate were reconstructed by a filtered back-projection algorithm. Furthermore, the temperature rise on the urethra surface caused by a transurethral PAE was evaluated with COMSOL Multiphysics to verify the thermal safety issue.
Results: Transurethral PAE simultaneously increased the laser penetration depth and improved the imaging quality compared to a transrectal one. There was only 4 mK temperature rise caused by a transurethral PAE on the urethra surface during the photoacoustic imaging, which caused no thermal damage to the urethra. A linear relationship between the therapeutic drug concentrations and the PA amplitude was observed from the simulation results, revealing the potential of using transurethral PAE for drug delivery monitoring in prostate cancer therapy.
Conclusion: Simulation results of this study validated the feasibility of using a PA technique to monitoring laser-induced therapy for prostate cancer. This will greatly enhance the potential of prostate PAE for in vivo monitoring of drug delivery and guidance of the laser-induced therapy for future clinical use.
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