Program Information
Multifunctional Radiotherapy Biomaterials
M Moreau123, S Yasmin-Karim23, R Mueller23, W Ngwa1234, (1) University of Massachusetts Lowell, Lowell, MA, (2) Brigham and Women's Hospital, Boston, Massachusetts, (3) Dana Farber Cancer Institute, Boston, MA, (4) Harvard Medical School, Boston, MA
Presentations
TU-C2-GePD-T-5 (Tuesday, August 1, 2017) 10:00 AM - 10:30 AM Room: Therapy ePoster Lounge
Purpose: To establish an innovative brand of multifunctional radiotherapy biomaterials (fiducials, spacers, beacons) (MRBs) which can accomplish high spatial accuracy during radiotherapy but also deliver high capacity payloads of nanoparticles to enhance local and metastatic tumor cell kill with -minimal collateral damage.
Methods: Multifunctional Biomaterials (MBs) were fabricated with high capacity reservoirs for loading payloads of nanoparticles. Biomaterials were made using a Poly (D,L-lactide-co-glycolide) (PLGA) polymer mixed with DMSO to form a hydrogel solution to load into silicon tubing (ID:1/16” or ID:1/32”) using the Harvard Apparatus. Payloads investigated included gadolinium nanoparticles (GdNPs), and gold nanoparticles (GNPs). The continuous release of the payload was examined using de-ionized water, and small animals with pancreatic subcutaneous tumors. Spacer implant in tumors was done using a brachy-therapy needle. Release was monitored using magnetic resonance imaging (MRI), computed tomography (CT) imaging with the Small Animal Radiation Research Platform (SARRP) at 65 kVp.
Results: An MRI using a magnetic field of 7Tesla demonstrated a release rate of GdNPs to be 0.03uM per day in-vitro. These spacers can be further customized to modify released rate. The CT raw-data of the mouse tumors showed a decrease in signal of GNP loaded spacer over 8 days time frame which was also confirmed using the Weber Contrast in the reconstructed images. The maximum intensity projections of the tumor showed a faster release along the length of the spacer compared to its radial counterpart.
Conclusion: The in-vitro and in-vivo release results reveal major potential for novel multifunctional radiotherapy biomaterials which can be employed for sustained image-guided delivery of radio-sensitizers or immune-adjuvants to boost both local and metastatic tumor kill with negligible systemic toxicities which are major limitations to competing approaches.
Contact Email: