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HyTEC 2106 - Single- and Multifraction Stereotactic Radiosurgery Dose/Volume Tolerances of the Brain (2020)

Category: HyTEC

Pooled published data reveal that radiation-induced brain toxicity after single-fraction stereotactic radiosurgery for brain metastases and arteriovenous malformations is low when the volume of tissue receiving 12 Gy is less than 5 cm3 but increases with larger treatment volumes. Fractionated stereotactic radiosurgery can reduce toxicity risk for larger targets. Standardized dosimetric and toxicity reporting would facilitate future pooled analyses and predict brain toxicity risks more precisely.

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International Journal of Radiation Oncology*Biology*Physics

Michael T. Milano, MD, PhD, Jimm Grimm, PhD, Andrzej Niemierko, PhD, Scott G. Soltys, MD, Vitali Moiseenko, PhD, Kristin J. Redmond, MD, Ellen Yorke, PhD, Arjun Sahgal, MD, Jinyu Xue, PhD, Anand Mahadevan, MD, Alexander Muacevic, MD, Lawrence B. Marks, MD, and Lawrence R. Kleinberg, MD

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