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Report No. 089 - Genetic Effects From Internally Deposited Radionuclides (1987)

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It was learned in the late 1920s that ionizing radiation could produce genetic effects such as gene mutations and chromosome aberrations. However, at least until 1945, the focus of interest in radiation protection was primarily on somatic effects manifested in the individual exposed. Studies of the genetic effects of radiation using drosophila, however, refocused attention on effects transmitted to the exposed individuals offspring and concern over fallout in the 1950's resulted in efforts to estimate the genetic effects from exposure of human populations to internally deposited radionuclides. No human populations have been identified with burdens of internally deposited radioactive materials which have been shown to produce evidence of transmissible genetic damage. As a result, the research approach has been one in which macromolecular, cellular, and whole animal genetic studies have been combined to estimate genetic effects on humans following the deposition of radioactive materials in the body. The purpose of this report is to update the information available from animal and cellular experiments that relates genetic effects to deposited activity and dose from internally deposited radioactive materials. For the various radiation types, genetic data for internally deposited radioactive materials are compared with those derived from exposure to external acute or protracted radiation to estimate the relative genetic hazard.
Scientific Committee:
Antone L. Brooks, Choirman

Douglas Grahn
William L. Russell
Paul B. Selby
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