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Report No. 150 - Extrapolation of Radiation-Induced Cancer Risks from Nonhuman Experimental Systems to Humans (2005)  Price: $75 PDF (AAPM Members FREE) Category: Reports This Report reviews the scientific issues associated with the extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans. The basic principles of radiation effects at the molecular and cellular level are examined with emphasis on comparisons among various species including humans. These comparisons among species are then continued for cancers of similar cell types in the same organ system. Risk estimates are made from an observed level of effect as a function of organ dose. The major organ systems are individually considered. Extrapolation models are reviewed and include external and internal radiation exposures. ISBN 0-929600-86-X View the latest Book Review of this Report. Scientific Committee: David G. Hoel, Chairman Bruce A. Carnes Robert L. Dedrick R.J. Michael Fry Douglas Grahn William C. Griffith Peter G. Groer R. Julian Preston Consultants: Kelly H. Clifton Scott C. Miller Hildegard M. Shuller Thomas M. Seed |
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