Program Information
Dosimetric Advantage of Volumetric Modulated Arc Therapy in the Treatment of Intraocular Cancer
X Jin1*, Z Deng2 , C Xie3 , (1) 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, ,(2) the 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, (3) the 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang
Presentations
SU-I-GPD-T-411 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: The purpose of this study is to investigate the dosimetric advantages of volumetric modulated arc therapy (VMAT) in the treatment of intraocular cancer by comparing it directly with three-dimensional conformal radiotherapy (CRT) and intensity-modulated radiotherapy (IMRT).
Methods: CRT plan, 7f-IMRT plan, and one-arc VMAT plan were generated for 14 intraocular cancer patients. Dosimetric and biological quality indices for target volume and organs at risks (OARs) were evaluated and compared.
Results: The target coverage presented by V95 for CRT, IMRT and VMAT were 95.02%±0.67%, 95.51%±2.25%, and 95.92%±3.05%, respectively. VMAT and IMRT plans achieved a higher tumor control probability (TCP) compared with CRT plans, but without significant difference. IMRT and VMAT greatly decreased the dose to ipsilateral lens compared with CRT with a D1 of 2972.66±1407.12 cGy, 3317.82±915.28 cGy and 4809.54±524.60 cGy for IMRT, VMAT and CRT, respectively. Similar results were observed for ipsilateral eyeballs. IMRT and VMAT also spared better on brainstem, optical nerves and optical chiasm compared CRT. However, CRT achieved lower dose to contralateral lens and eyeballs compared with IMRT and VMAT. VMAT and IMRT showed mixed results on target coverage and OAR sparing. The average MUs and delivery time of IMRT and VMAT were 531.25±81.21 vs. 400.99±61.49 and 5.05±0.53 vs.1.71±0.69 minutes, respectively.
Conclusion: Although no clear distinction on PTV coverage among CRT, IMRT and VMAT plans was observed, VMAT and IMRT achieved better homogeneity and conformity for target volume, and delivered fewer doses to ipsilateral lens and eyeballs compared with CRT. However, VMAT and IMRT increased the low dose volume to the contralateral OARs. Although VMAT and IMRT showed mixed results on target coverage and OAR sparing, VMAT decreased MU and delivery time significantly compared with IMRT. VMAT is a promising and feasible external beam radiotherapy technique in the treatment of intraocular cancer patients.
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