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Peak Temperature Ratio of TLD Glow Curves to Investigate the Spatial Dependence of LET in a Clinical Proton Beam

C Reft

C Reft1*, M Pankuch2 , H Ramirez3 , (1) Univ Chicago, Chicago, IL, (2) ProCure Treatment Centers, Warrenville, IL, (3) ProCure Treatment Centers,Warrenville, IL


SU-E-T-354 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: Use the ratio of the two high temperature peaks (HTR) in TLD 700 glow curves to investigate spatial dependence of the linear energy transfer (LET) in proton beams. Studies show that the relative biological effectiveness (RBE) depends upon the physical dose as well as its spatial distribution. Although proton therapy uses a spatially invariant RBE of 1.1, studies suggest that the RBE increases in the distal edge of a spread out Bragg peak (SOBP) due to the increased LET.

Methods: Glow curve studies in TLD 700 show that the 280 C temperature peak is more sensitive to LET radiation than the 210 C temperature peak. Therefore, the areas under the individual temperature peaks for TLDs irradiated in a proton beam normalized to the peak ratio for 6 MV photons are used to determine the HTR to obtain information on its LET. TLD 700 chips with dimensions 0.31x0.31x0.038 cc are irradiated with 90 MeV protons at varying depths in a specially designed blue wax phantom to investigate LET spatial dependence.

Results: Five TLDs were placed at five different depths of the percent depth dose curve (PDD) of range 16.2 cm: center of the SOPB and approximately at the 99% distal edge, 90%, 75% and 25% of the PDD, respectively. HTR was 1.3 at the center of the SOBP and varied from 2.2 to 3.9 which can be related to an LET variation from 0.5 to 18 KeV/μ via calibration with radiation beams of varying LET.

Conclusion: HTR data show a spatially invariant LET slightly greater than the 6 MV radiations in the SOBP, but a rapidly increasing LET at the end of the proton range. These results indicate a spatial variation in RBE with potential treatment consequences when selecting treatment margins to minimize the uncertainties in proton RBE.

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