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Establishment and Implement of 3D Image Guided Brachytherapy Planning System

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S Jiang

S Jiang1*, S Zhao1 , Y Chen1 , Z Li1 , P Li1 , Z Huang1 , Z Yang1 , X Zhang2 , (1) Tianjin University, Tianjin, China (2) Seeds biological Pharmacy Ltd, Tianjin, China


SU-E-T-154 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Cannot observe the dose intuitionally is a limitation of the existing 2D pre-implantation dose planning. Meanwhile, a navigation module is essential to improve the accuracy and efficiency of the implantation. Hence a 3D Image Guided Brachytherapy Planning System conducting dose planning and intra-operative navigation based on 3D multi-organs reconstruction is developed.

Multi-organs including the tumor are reconstructed in one sweep of all the segmented images using the multi-organs reconstruction method. The reconstructed organs group establishs a three-dimensional visualized operative environment. The 3D dose maps of the three-dimentional conformal localized dose planning are calculated with Monte Carlo method while the corresponding isodose lines and isodose surfaces are displayed in a stereo view. The real-time intra-operative navigation is based on an electromagnetic tracking system (ETS) and the fusion between MRI and ultrasound images. Applying Least Square Method, the coordinate registration between 3D models and patient is realized by the ETS which is calibrated by a laser tracker. The system is validated by working on eight patients with prostate cancer. The navigation has passed the precision measurement in the laboratory.

The traditional marching cubes (MC) method reconstructs one organ at one time and assembles them together. Compared to MC, presented multi-organs reconstruction method has superiorities in reserving the integrality and connectivity of reconstructed organs. The 3D conformal localized dose planning, realizing the "exfoliation display" of different isodose surfaces, helps make sure the dose distribution has encompassed the nidus and avoid the injury of healthy tissues. During the navigation, surgeons could observe the coordinate of instruments real-timely employing the ETS. After the calibration, accuracy error of the needle position is less than 2.5mm according to the experiments.

The speed and quality of 3D reconstruction, the efficiency in dose planning and accuracy in navigation all can be improved simultaneously.

Funding Support, Disclosures, and Conflict of Interest: 1) National Natural Science Foundation of People's Republic of China (No. 51175373). 2) New Century Educational Talents Plan of Chinese Education Ministry (NCET-10-0625). 3) Scientific and Technological Major Project, Tianjin (No. 12ZCDZSY10600).

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