Program Information
Research of the Irradiation Damage to the Skin Cell by the Contaminative Electron in External Radiotherapy
Z Xiong1*, H Lin1 , J Jing1 , J Cai1,2 , Y Dai1 (1) Hefei University of Technology, Hefei, China; (2) Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei,China
Presentations
SU-E-T-283 Sunday 3:00PM - 6:00PM Room: Exhibit HallPurpose: To investigate the micro-damage mechanism of the contaminative electron to the skin cell in external radiotherapy, the cell damage yield was simulated.
Methods: The physical interaction and the energy deposited events of contaminative electrons in the cell DNA were modeled based on Geant4-DNA low energy physical model. The density-based cluster mining algorithm was used to analyze the micro-damage yield and obtain its detailed compositive information. By taking the irradiation sensitive parameter and the clinical feature dose threshold of the skin cell into consideration, the damage features of the low energy contaminative electron to the skin cell were studied. The DSB and SSB yield and ratio, the cluster size and the root mean square radius, the cell SF and the lethal coefficient ε of the complex cDSB were researched.
Results: For some very low energy electrons such as 20keV and 100keV, the cluster size can be more than 5 SSBs. The irradiation protection will be more crucial for the later response and the high α tissue. The lethal coefficient ε of the complex cDSB will increase with the incident electron number and the accumulative dose increasing for the dose square term in LQ model. However, the ε increment will increase 3%~15% when the incident electron increases up to 100000.
Conclusion: The simulation of the direct physical damage of the cell can be adjusted by a probability parameter to offset the simulation of the indirect biochemical damage. Thus the micro-damage mechanism of the contaminative electron to the skin cell can be detected at a certain extent by Monte Carlo physical simulation. This damage model of the low energy electron to DNA and these simulated results could be used to evaluate the damage effect of the low energy contaminative electron to the skin cells in the external radiotherapy.
Funding Support, Disclosures, and Conflict of Interest: Strategic Priority Research Program of the Chinese Academy of Sciences(XDA03040000), Fundamental Research Funds for the Central Universities (2012HGXJ0057,2013HGXJ0193), Seed Foundation of Hefei University of Technology (2012HGZY0007)and Hefei University of Technology undergraduate innovative experiment project(2012CXCY431)
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