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Automatic Beam Angle Determination for Lung IMRT Planning Using a Beam Configuration Atlas

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L Yuan

L Yuan1*, Y Ge2 , F Yin1 , Y Li3 , Y Sheng1 , Q J. Wu1 , (1) Duke University Medical Center, Durham, NC, (2) University of North Carolina at Charlotte, Charlotte, NC, (3) The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing


SU-E-T-49 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

To present a technique to automatically determine beam angle configurations for lung IMRT planning based on the patient-specific anatomy and tumor geometry.
The relationship between individual patient anatomy and proper beam configurations was learned from high quality clinical plans in three steps. First, a beam configuration atlas was obtained by classifying 60 lung IMRT plans into 6 beam configuration clusters based on a dissimilarity measure defined between different beam configurations. A beam configuration template was extracted from each cluster to form an atlas. Second, a beam efficiency index map (EI map) was constructed to characterize the geometry of the tumor relative to the lungs, the body and other OARs along each candidate beam direction. Finally, the EI maps of the clinical cases and the cluster assignments of their beam configurations were paired to train a Bayesian classification model. This technique was validated by leave-one-out cross validation with 16 cases randomly selected from the original dataset. An IMRT plan (auto-beam plan) for each test case was generated using the beam configuration template according to the cluster assignment given by the model and was compared with the corresponding clinical plan.
The dosimetric parameters (mean±S.D. in percentage of prescription dose) in the auto-beam plans and in the clinical plans, respectively, and the p-values by a paired t-test (in parenthesis) are: lung Dmean: 16.3±9.3, 18.6±7.4 (0.48), esophagus Dmean: 28.4±18, 30.7±19.3 (0.02), Heart Dmean: 21.5±17.5,21.1±17.2 (0.76), Spinal Cord D2%: 48±23, 51.2±21.8 (0.01), PTV dose homogeneity (D2%-D99%): 22±27.4, 20.4±12.8 (0.10).
The dose reductions by the auto-beam plans in esophagus Dmean and cord D02 are statistically significant but the differences (<4%) may not be clinically significant. The other dosimetric parameters are not statistically different.
Plans generated by the automatic beam angle determination method can achieve dosimetric quality equivalent to that of clinical plans.

Funding Support, Disclosures, and Conflict of Interest: Partially supported by NIH/NCI under grant #R21CA161389 and a master research grant by Varian Medical System.

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