Encrypted login | home

Program Information

How Iterative Reconstruction Algorithms Affect the MTFs of Variable-Contrast Targets in CT Images

no image available
C Dodge

C.T. Dodge1*, J. Rong1, C.W. Dodge2, (1) MD Anderson Cancer Center, Houston, TX, (2) Methodist Hospital, Houston, TX


WE-D-18A-4 Wednesday 11:00AM - 12:15PM Room: 18A

Purpose: To determine how filtered back-projection (FBP), adaptive statistical (ASiR), and model based (MBIR) iterative reconstruction algorithms affect the measured modulation transfer functions (MTFs) of variable-contrast targets over a wide range of clinically applicable dose levels.

Methods: The Catphan 600 CTP401 module, surrounded by an oval, fat-equivalent ring to mimic patient size/shape, was scanned on a GE HD750 CT scanner at 1, 2, 3, 6, 12 and 24 mGy CTDIvol levels with typical patient scan parameters: 120kVp, 0.8s, 40mm beam width, large SFOV, 2.5mm thickness, 0.984 pitch. The images were reconstructed using GE’s Standard kernel with FBP; 20%, 40% and 70% ASiR; and MBIR. A task-based MTF (MTFtask) was computed for six cylindrical targets: 2 low-contrast (Polystyrene, LDPE), 2 medium-contrast (Delrin, PMP), and 2 high-contrast (Teflon, air). MTFtask was used to compare the performance of reconstruction algorithms with decreasing CTDIvol from 24mGy, which is currently used in the clinic.

Results: For the air target and 75% dose savings (6 mGy), MBIR MTFtask at 5 lp/cm measured 0.24, compared to 0.20 for 70% ASiR and 0.11 for FBP. Overall, for both high-contrast targets, MBIR MTFtask improved with increasing CTDIvol and consistently outperformed ASiR and FBP near the system’s Nyquist frequency. Conversely, for Polystyrene at 6 mGy, MBIR (0.10) and 70% ASiR (0.07) MTFtask was lower than for FBP (0.18). For medium and low-contrast targets, FBP remains the best overall algorithm for improved resolution at low CTDIvol (1-6 mGy) levels, whereas MBIR is comparable at higher dose levels (12-24 mGy).

Conclusion: MBIR improved the MTF of small, high-contrast targets compared to FBP and ASiR at doses of 50%-12.5% of those currently used in the clinic. However, for imaging low- and medium-contrast targets, FBP performed the best across all dose levels. For assessing MTF from different reconstruction algorithms, task-based MTF measurements are necessary.

Contact Email: