Encrypted login | home

Program Information

Optically Stimulated Luminescence Detectors as 'LET-Meters' in Proton Beams

D Granville

D Granville1*, N Sahoo2, GO Sawakuchi2, (1) Carleton Laboratory for Radiotherapy Physics, Carleton University, Ottawa, ON, (2) The Univerity of Texas MD Anderson Cancer Center, Houston, TX


WE-D-17A-6 Wednesday 11:00AM - 12:15PM Room: 17A

Purpose: To demonstrate and evaluate the potential of optically stimulated luminescence (OSL) detectors (OSLDs) for measurements of linear energy transfer (LET) in therapeutic proton beams.

Methods: Batches of Al₂O₃:C OSLDs were irradiated with an absorbed dose of 0.2 Gy in un-modulated proton beams of varying LET (0.67 keV/μm to 2.58 keV/μm). The OSLDs were read using continuous wave (CW-OSL) and pulsed (P-OSL) stimulation modes. We parameterized and calibrated three characteristics of the OSL signals as functions of LET: CW-OSL curve shape, P-OSL curve shape and the ratio of the two OSL emission band intensities (ultraviolet/blue ratio). Calibration curves were created for each of these characteristics to describe their behaviors as functions of LET. The true LET values were determined using a validated Monte Carlo model of the proton therapy nozzle used to irradiate the OSLDs. We then irradiated batches of OSLDs with an absorbed dose of 0.2 Gy at various depths in two modulated proton beams (140 MeV, 4 cm wide spread-out Bragg peak (SOBP) and 250 MeV, 10 cm wide SOBP). The LET values were calculated using the OSL response and the calibration curves. Finally, measured LET values were compared to the true values determined using Monte Carlo simulations.

Results: The CW-OSL curve shape, P-OSL curve shape and the ultraviolet/blue-ratio provided proton LET estimates within 12.4%, 5.7% and 30.9% of the true values, respectively.

Conclusion: We have demonstrated that LET can be measured within 5.7% using Al₂O₃:C OSLDs in the therapeutic proton beams used in this investigation. From a single OSLD readout, it is possible to measure both the absorbed dose and LET. This has potential future applications in proton therapy quality assurance, particularly for treatment plans based on optimization of LET distributions.

Funding Support, Disclosures, and Conflict of Interest: This research was partially supported by the Natural Sciences and Engineering Research Council of Canada.

Contact Email: