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Improving the Quality of T2-Weighted 4D Magnetic Resonance Imaging for Clinical Evaluation

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D Du

D Du1*, S Caruthers2 , C Glide-Hurst3 , D Low4 , S Mutic1 , Y Hu1 , (1) Washington University School of Medicine, Saint Louis, MO, (2) Philips Healthcare, Cleveland, OH, (3) Henry Ford Health System, Detroit, MI, (4) UCLA, Los Angeles, CA


SU-E-J-157 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: To develop an imaging technique that enables us to acquire T2-weighted 4D Magnetic Resonance Imaging (4DMRI) with sufficient spatial coverage, temporal resolution and spatial resolution for clinical evaluation.

Methods: T2-weighed 4DMRI images were acquired from a healthy volunteer using a respiratory amplitude triggered T2-weighted Turbo Spin Echo sequence. 10 respiratory states were used to equally sample the respiratory range based on amplitude (0%, 20%i, 40%i, 60%i, 80%i, 100%, 80%e, 60%e, 40%e and 20%e). To avoid frequent scanning halts, a methodology was devised that split 10 respiratory states into two packages in an interleaved manner and packages were acquired separately. Sixty 3mm sagittal slices at 1.5mm in-plane spatial resolution were acquired to offer good spatial coverage and reasonable spatial resolution. The in-plane field of view was 375mm x 260mm with nominal scan time of 3 minutes 42 seconds. Acquired 2D images at the same respiratory state were combined to form the 3D image set corresponding to that respiratory state and reconstructed in the coronal view to evaluate whether all slices were at the same respiratory state. 3D image sets of 10 respiratory states represented a complete 4D MRI image set.

Results: T2-weighted 4DMRI image were acquired in 10 minutes which was within clinical acceptable range. Qualitatively, the acquired MRI images had good image quality for delineation purposes. There were no abrupt position changes in reconstructed coronal images which confirmed that all sagittal slices were in the same respiratory state.

Conclusion: We demonstrated it was feasible to acquire T2-weighted 4DMRI image set within a practical amount of time (10 minutes) that had good temporal resolution (10 respiratory states), spatial resolution (1.5mm x 1.5mm x 3.0mm) and spatial coverage (60 slices) for future clinical evaluation.

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