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Automated Detection of Anatomic Changes in H&N Patients

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A Usynin

A Usynin*, C Ramsey , Thompson Cancer Survival Center, Knoxville, TN


SU-E-J-191 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: To develop a novel statistics-based method for automated detection of anatomical changes using cone-beam CT data. A method was developed that can provide a reliable and automated early warning system that enables a “just-in-time” adaptation of the treatment plan.

Methods: Anatomical changes were evaluated by comparing the original treatment planning CT with daily CBCT images taken prior treatment delivery. The external body contour was computed on a given CT slice and compared against the corresponding contour on the daily CBCT. In contrast to threshold-based techniques, a statistical approach was employed to evaluate the difference between the contours using a given confidence level. The detection tool used the two-sample Kolmogorov-Smirnov test, which is a non-parametric technique that compares two samples drawn from arbitrary probability distributions. 11 H&N patients were retrospectively selected from a clinical imaging database with a total of 186 CBCT images. Six patients in the database were confirmed to have anatomic changes during the course of radiotherapy. Five of the H&N patients did not have significant changes. The KS test was applied to the contour data using a sliding window analysis. The confidence level of 0.99 was used to moderate false detection.

Results: The algorithm was able to correctly detect anatomical changes in 6 out of 6 patients with an excellent spatial accuracy as early as at the 14th elapsed day. The algorithm provided a consistent and accurate delineation of the detected changes. The output of the anatomical change tool is easy interpretable, and can be shown overlaid on a 3D rendering of the patient’s anatomy.

Conclusion: The detection method provides the basis for one of the key components of Adaptive Radiation Therapy. The method uses tools that are readily available in the clinic, including daily CBCT imaging, and image co-registration facilities.

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