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Investigating Magnetic Field Dose Effects in Mice: A Monte Carlo Study

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A Rubinstein

A Rubinstein*, M Guindani , D Followill , A Melancon , J Hazle , L Court , UT MD Anderson Cancer Center, Houston, TX


MO-G-BRF-9 Monday 4:30PM - 6:00PM Room: Ballroom F

Purpose:In MRI-linac treatments, radiation dose distributions are affected by magnetic fields, especially at high-density/low-density interfaces. Radiobiological consequences of magnetic field dose effects are presently unknown; therefore, preclinical studies are needed to ensure the safe clinical use of MRI-linacs. This study investigates the optimal combination of beam energy and magnetic field strength needed for preclinical murine studies.

Methods:The Monte Carlo code MCNP6 was used to simulate the effects of a magnetic field when irradiating a mouse-sized lung phantom with a 1.0cmx1.0cm photon beam. Magnetic field effects were examined using various beam energies (225kVp, 662keV[Cs-137], and 1.25MeV[Co-60]) and magnetic field strengths (0.75T, 1.5T, and 3T). The resulting dose distributions were compared to Monte Carlo results for humans with various field sizes and patient geometries using a 6MV/1.5T MRI-linac.

Results:In human simulations, the addition of a 1.5T magnetic field caused an average dose increase of 49% (range:36%-60%) to lung at the soft tissue-to-lung interface and an average dose decrease of 30% (range:25%-36%) at the lung-to-soft tissue interface. In mouse simulations, the magnetic fields had no effect on the 225kVp dose distribution. The dose increases for the Cs-137 beam were 12%, 33%, and 49% for 0.75T, 1.5T, and 3.0T magnetic fields, respectively while the dose decreases were 7%, 23%, and 33%. For the Co-60 beam, the dose increases were 14%, 45%, and 41%, and the dose decreases were 18%, 35%, and 35%.

Conclusion:The magnetic field dose effects observed in mouse phantoms using a Co-60 beam with 1.5T or 3T fields and a Cs-137 beam with a 3T field compare well with those seen in simulated human treatments with an MRI-linac. These irradiator/magnet combinations are suitable for preclinical studies investigating potential biological effects of delivering radiation therapy in the presence of a magnetic field.

Funding Support, Disclosures, and Conflict of Interest: Partially funded by Elekta.

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